Making sense of antisense oligonucleotide therapy
نویسندگان
چکیده
منابع مشابه
Making sense of antisense therapy for hypertension.
ed in the regulation of vascular tone. Whilst pharmacological antagonism of ‚-adrenoceptors is still part of the mainstay treatment for hypertension, ·adrenoreceptor blockade is rarely used as a front line therapy. In the ALLHAT study peripheral ·-blockade in high risk hypertensive patients led to a 25% increase in cardiovascular events and doubled the likelihood of hospital admissions. Althoug...
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Neuromuscular disorders such as Duchenne Muscular Dystrophy and Spinal Muscular Atrophy are neurodegenerative genetic diseases characterized primarily by muscle weakness and wasting. Until recently there were no effective therapies for these conditions, but antisense oligonucleotides, a new class of synthetic single stranded molecules of nucleic acids, have demonstrated promising experimental r...
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Neurotoxicity from accumulation of misfolded/mutant proteins is thought to drive pathogenesis in neurodegenerative diseases. Since decreasing levels of proteins responsible for such accumulations is likely to ameliorate disease, a therapeutic strategy has been developed to downregulate almost any gene in the CNS. Modified antisense oligonucleotides, continuously infused intraventricularly, have...
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ژورنال
عنوان ژورنال: Prescriber
سال: 2020
ISSN: 0959-6682,1931-2253
DOI: 10.1002/psb.1848